The Argentine struck twice, as the champions hammered Bournemouth 4-1 last weekend, to take his tally to six for this campaign.
His team-mate Raheem failed to score, just like Norwich City’s Teemu Pukki. Both are on five goals.
Tammy Abraham netted another brace, as Chelsea were held to a 2-2 draw by Sheffield United.
Premier League Top Scorers
6 goals: Sergio Agüero (Manchester City)
5 goals: Teemu Pukki (Norwich City), Raheem Sterling (Manchester City)
4 goals: Tammy Abraham (Chelsea), Ashley Barnes (Burnley)
3 goals: Mohamed Salah (Liverpool), Jamie Vardy (Leicester City), Sébastien Haller (West Ham), Daniel James (Manchester United), Pierre-Emerick Aubameyang (Arsenal), Harry Kane (Tottenham Hotspur)
2 goals: Firmino (Liverpool), Sadio Mané (Liverpool), Anthony Martial (Manchester United), Marcus Rashford (Manchester United), Alexandre Lacazette (Arsenal), Harry Wilson (Bournemouth), Jordan Ayew (Crystal Palace), Richarlison (Everton), Raúl Jiménez (Wolves), Mason Mount (Chelsea)